leukotriene b4 receptors การใช้

It acts as a leukotriene B4 receptor antagonist and a PPAR? agonist.
Discovered several years after the leukotriene B4 receptor 1 ( BLT1 ), BLT2 receptor binds leukotriene B4 ( LTB4 ) with far lower affinity than the BLT1 receptor does and therefore has been termed the "'low affinity LTB4 receptor " '.
15 ( " S " )-HpETE and 15 ( " S " )-HETE bind to the G protein-coupled receptor, Leukotriene B4 receptor 2, i . e . BLT2; this receptor may mediate at least some of their stimulatory activities.
One or both of these compounds stimulates cells by binding with and activating two G protein-coupled receptors, GPR31 and the Leukotriene B4 receptor 2; 12 " S "-HETE also acts as a receptor antagonist by binding to but not stimulating the Thromboxane receptor thereby inhibiting the actions of Thromboxane A2 and Prostaglandin H2 ( see 12-Hydroxyeicosatetraenoic acid # Receptor targets and mechanisms of action ).
Since a previously discovered arachidonic acid metabolite made by neutrophils, leukotriene B4 ( LTB 4 ), also stimulates human neutrophil calcium rises, chemotaxis, and auto-aggregation and is structurally similar to 5 ( " S " )-HETE in being a 5-( " S " )-hydroxy-eicosateraenoate, it was assumed that 5-( " S " )-HETE stimulated cells through the same cell surface receptors as those used by ( LTB 4 ) viz ., the leukotriene B4 receptors.